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le 22 janvier 2019

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David Danan

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Mardi 22 janvier 2019 à 09h45
David Danan
LTSI, INSERM, Rennes, France
Titre : Toward a better understanding of cardiovascular diseases:
a multi-formalism model-based approach with specific-patient features

Résumé : Accurately modeling cardiac mechanics remains, even nowadays, a particularly challenging problem as it involves multi-physical coupled phenomena (mechanical, electrical and hemodynamical), and because of the poor understanding of the underlying physiology. Here, we focus on the description of a left ventricle (LV) model that couples finite element electrical model (propagation of the transmembrane potential through the LV) to a finite element mechanical model (LV wall deformation) while being ruled over by a 0D circulatory model that governs the different classical phases of a cardiac cycle. The aim of the MAESTRo project was to develop a tool using the aforementioned model-based approach to simulate the behavior of the left ventricle in order to obtain the 3D strain signals associated to its deformation.
First, using the strain signals and pressure-volume loop arising from the simulations, we illustrate the model ability to reproduce the four basic phases of the cardiac cycle in a physiological case. Next, we propose a sensitivity analysis of a 3D model of the left ventricle in order to assess the influence of parameters on myocardial mechanical dispersion. A finite element model (FEM) of LV electro-mechanical activity was considered and a screening method was used to evaluate the sensitivity of model parameters on the standard deviation of time to peak strain (TPS-SD).
The sensitivity analysis results highlight the importance of propagation parameters associated with septal and lateral segments.
Simulated curves were confronted to myocardial strains, arising from the echocardiography of one healthy subject and one patient diagnosed with intraventricular dyssynchrony and coronary arteries disease. The first results show a close match between simulation and clinical strains and illustrate the model ability to reproduce myocardial strains in the context of intraventricular dyssynchrony.


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Mise à jour le 17 janvier 2019